Fatty Livers Induced by Orotic Acid
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چکیده
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Fatty Livers Induced by Orotic Acid
Rats fed a purified diet supplemented with erotic acid (1%) have gross alterations in their lipid metabolism that can be essentially nullified by further supplementation of the diet with adenine sulfate (0.25%), as described in the first paper of this series (1). Accompanying these changes are certain alterations in the metabolism of pyrimidine derivatives, which have been described in an earli...
متن کاملFatty livers induced by orotic acid. II. Changes in nucleotide metabolism.
Rats fed a purified diet supplemented with erotic acid (1%) have gross alterations in their lipid metabolism that can be essentially nullified by further supplementation of the diet with adenine sulfate (0.25%), as described in the first paper of this series (1). Accompanying these changes are certain alterations in the metabolism of pyrimidine derivatives, which have been described in an earli...
متن کاملIsolation and Characterization of Low Density Structures from Orotic Acid-induced Fatty Livers
Centrifugation of a sucrose homogenate of the livers of female albino rats fed a 1.5% orotic acid diet for 3 wk yielded a pellicle containing low density structures. In morphology and biochemical properties these structures resembled those portions of endoplasmic reticulum which accumulated lipid. Electron microscopy indicated large droplets of lipid bounded by a membrane with attached ribosome...
متن کاملDietary Adenine Alleviates Fatty Liver Induced by Orotic Acid
The effects of dietary adenine in fatty liver induced by orotic acid (OA) were studied. Rats were paired-fed 1% OA-supplemented diets with/or without 0.25% adenine or a diet without OA for 10 days. Serum lipid profiles were measured using enzyme assay kits. Lipids of liver tissues were extracted and liver lipid contents were determined. A peach of liver was prepared to determine the activities ...
متن کاملBiochemical and Nutritional Studies on the Induction of Fatty Livers by Dietary Orotic Acid.
3Canellakis, E. S., Biochim. Biophys. Acta, 25, 217 (1957). 4Hecht, L. I., P. C. Zamecnik, M. L. Stephenson, and J. F. Scott, J. Biol. Chem., 233, 954 (1958). 6 Zachau, H. G., G. Acs, and F. Lipmann, these PROCEEDINGS, 44, 885 (1958). 6 Preiss, J., P. Berg, J. Ofengand, F. H. Bergman, and M. Dieckman, these PROCVEDINGS, 45, 319 (1959). 7Hecht, L. I., M. L. Stephenson, and P. C. Zamecnik, these ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1963
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)67994-9